Chronic Effects of Neurotrauma Consortium Chronic Effects of Neurotrauma Consortium

Chronic Effects of Neurotrauma Consortium

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CENC Cycle 2, 2019-2023

On Friday, June 14, 2019, the Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC) Award application submission by Virginia Commonwealth University was recommended for funding. Specific details about CENC Cycle 2 will be updated on this website as they become available; however, the sections below describe the proposed Studies and Cores that were part of the LIMBIC application.

Studies


Principal Investigator Contact Information
Dr. William Walker, M.D. william.walker@vcuhealth.org

Study description: The Prospective Longitudinal Study aims to continue the research successfully conducted during CENC Cycle 1, as well as expand the current active cohort of 1,500 Service Members and Veterans. Throughout the duration of CENC Cycle 2, the Prospective Longitudinal Study will refine methods, enhance analyses, and apply results to identify predictors and longitudinal effects of mTBI.

If you are a Service Member or Veteran interested in being a participant for this study, click on the following link for additional information: Participate in CENC Research.


Principal Investigator Contact Information
Dr. Kristine Yaffe, M.D. Kristine.Yaffe@ucsf.edu

Study description: The Retrospective Database Study aims to maintain, augment, and refine the database of 1.6 million Veterans, created during CENC Cycle 1, as well as expand analyses and application of results. During CENC Cycle 2, the Retrospective Database Study will conduct analyses to identify, examine, and elucidate outcome predictors, comorbidities, and neurodegenerative sequelae associated with mTBI, ultimately aiming to apply results to development of prognostic models.

Cores


Location Website
Virginia Commonwealth University, https://www.vcu.edu/
Richmond, VA

Core description: The Coordinating Center manages and provides support for all consortium activities. Through individual and collective collaboration with CENC leadership, Core Directors, and Study personnel, the Coordinating Center ensures regulatory compliance, monitors progress, facilitates communication, and offers assistance, in order to promote success for each project, as well as the unified consortium.


Location Website
Hunter Holmes McGuire Veterans Affairs Medical Center, & https://www.richmond.va.gov/
Virginia Commonwealth University, https://www.vcu.edu/
Richmond, VA
VA Salt Lake City Health Care System, & https://www.saltlakecity.va.gov/
University of Utah, https://www.utah.edu/
Salt Lake City, UT

Core description: The Data and Biostatistics Core centrally and securely maintains all consortium data, provides biostatistical support, assists with study design functions, conducts data processing, and performs biostatistical analyses for manuscripts and presentations.


Location Website
Uniformed Services University of the Health Sciences, https://www.usuhs.edu/
Bethesda, MD

Core description: The Biomarkers Core manages the transfer, storage, and processing of all blood and saliva samples collected, for all consortium projects that conduct biospecimen collection procedures.


Location Website
VA Salt Lake City Health Care System, & https://www.saltlakecity.va.gov/
University of Utah, https://www.utah.edu/
Salt Lake City, UT

Core description: The Neuroimaging Core facilitates acquisition, review, transfer, collation, tracking, analysis, reporting, storage, and interpretation of neuroimaging data, for all consortium projects that conduct imaging procedures.


Location Website
Virginia Commonwealth University, https://www.vcu.edu/
Richmond, VA

Core description: The Clinical Studies Core prioritizes, organizes, facilitates, and monitors all clinical research activities across the consortium.

The Chronic Effects of Neurotrauma Consortium is jointly funded by the Department of Defense (award # W81XWH-13-2-0095) and the Department of Veterans Affairs (award #’s I01 CX001135, I01 CX001246, I01 RX001774, I01 RX001135, I01 RX002076, I01 RX001880, I01 RX002172, I01 RX002173, I01 RX002171, I01 RX002174, and I01 RX002170) / Created by VCU University Relations